A nice & detailed article comparing the Drupal CMS & the Django framework:

http://birdhouse.org/blog/2009/11/11/drupal-or-django/

 

It provides a nice overview of the 2. The authors conclude that:

 

Drupal represents a middle ground between framework and CMS that we’ve chosen not to take. Drupal is far more capable than a CMS like WordPress, but also much less flexible than a pure framework. But more importantly, the facts that Drupal isn’t object-oriented, isn’t MVC/MTV, doesn’t have an ORM, and is generally less flexible than a pure framework, not to mention our preference for working in Python over PHP, all contribute to our decision not to use it.